EARLY RENAL VASODILATOR AND HYPOTENSIVE ACTION OF EPOXYEICOSATRIENOIC ACID ANALOG (EET-A) AND 20-HETE RECEPTOR BLOCKER (AAA) IN SPONTANEOUSLY HYPERTENSIVE RATS

Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established New Barrels role in regulation of blood pressure (BP) and kidney function.EETs deficiency and increased renal formation of 20-HETE contribute to hypertension in spontaneously hypertensive rats (S

Aggregatibacter actinomycetemcomitans is a Gram-negative oral bacterium that has been primarily studied for its role in causing periodontal disease.The bacterium has also been implicated in several systemic diseases such as endocarditis and soft tissue abscesses.Leukotoxin (LtxA) is perhaps the best studied protein virulence factor from A.actinomyc

Introduction: Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) accompanies severe asthma in about 15% of the patients and may adversely affect the prognosis.Omalizumab and mepolizumab are biologics used in patients with severe asthma.The objective of this study is to assess the respiratory improvements, after the

A 53 year old female diagnosed with long term resistant schizophrenia, ischaemic heart disease and hypertension was treated with 700 mg/day of clozapine.Five months after commencing treatment, she complained of acute onset colicky abdominal pain and nausea with constipation of one days duration.Suspecting intestinal obstruction, she was referred fr

Abstract Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late nineteenth century, but it was only in the past fifty years that SL research surged in importance and PEPPERMINT LIQ CASTILE SOAP applicability.Currently, sphingolipids and their metabolism are hotly debated topics in various biochemical fields.Similar to other macrom